Home The 360FIVE™ Difference

The 360FIVE™ Difference

Each of our probiotic supplements are grounded in science and powered by 360FIVE, a proprietary blend of five diverse probiotic strains backed by over 700 research studies.

 

Strain 1: Lactobacillus rhamnosus GG

Lactobacillus rhamnosus GG

Lactobacillus rhamnosus GG is one of the first strains to be patented thanks to its ability to survive and grow rapidly in the gut.15 It is the #1 clinically studied probiotic strain backed by over 500 research studies and over 100 clinical studies. The proprietary Lactobacillus rhamnosus GG strain in Bio360® has been shown to be helpful in supporting healthy digestion*, stimulating an immune response* and inhibiting the growth of harmful bacteria to support a healthy inflammation response*.15,16 Lactobacillus rhamnosus has also shown benefits for cognitive health* and other gut-related disorders*.5,17


5. Bravo JA, et al. Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve. Proc Natl Acad Sci U S A. 2011;108(38):16050-16055.

15. Capurso L. Thirty Years of Lactobacillus rhamnosus GG: A Review. J Clin Gastroenterol. 2019;53 Suppl 1:S1-S41.

16. Johnson-Henry K.C, et al. Infection and Immunity 2008;76 (4) 1340-1348

17. Presti I, et al. Evaluation of the probiotic properties of new Lactobacillus and Bifidobacterium strains and their in vitro effect. Appl Microbiol Biotechnol. 2015;99(13):5613-5626

Strain 2: Bifidobacterium animalis subsp. lactis

Bifidobacterium animalis subsp. lactis

Referenced in 300 scientific publications and backed by over 130 clinical studies, Bifidobacterium animalis subsp. lactis strain is the world’s most documented probiotic Bifidobacterium and the second most studied probiotic species.18 Bifidobacterium animalis subsp. lactis is known for its superior ability to survive the gastric acids and deliver a full-range of benefits.* The benefits of Bifidobacterium animalis subsp. lactis strain in Bio360® includes improved digestive health*, increased regularity*, strengthened immune system* and reduced respiratory infections*.18


18. Jungersen M, et al. The Science behind the Probiotic Strain Bifidobacterium animalis subsp. lactis BB-12(®). Microorganisms. 2014;2(2):92-110.

Strain 3: Lactobacillus plantarum (WCFS1)

Lactobacillus plantarum WCFS1

Supported by over 200 research studies, Lactobacillus plantarum (WCFS1™) is the most independently studied probiotic and is often described as a ‘super probiotic’.2 Lactobacillus plantarum is known for its potential to support intestinal integrity in adults and in kids.* It helps keep unfriendly microbes, toxins, and allergens from wreaking havoc* in your gut.2 The specific Lactobacillus plantarum strain (WCFS1™) used in Bio360® has shown benefits for immune health* and its ability to survive gastric stress*.2 Lactobacillus plantarum strains have also shown benefits for skin health* and rebuilding the intestinal lining to support those with leaky gut*.9,17


2. van den Nieuwboer M, et al. Lactobacillus plantarum WCFS1 and its host interaction: a dozen years after the genome. Microb Biotechnol. 2016;9(4):452-465.

9. Ahrne S, et al. Effect of Lactobacilli on Paracellular Permeability in the Gut. Nutrients. 2011;3(1):104-117.

17. Presti I, et al. Evaluation of the probiotic properties of new Lactobacillus and Bifidobacterium strains and their in vitro effect. Appl Microbiol Biotechnol. 2015;99(13):5613-5626.

Strain 4: Lactobacillus fermentum

Lactobacillus fermentum

Lactobacillus fermentum, a probiotic strain known to survive the harshest conditions19 of the human gut, can be found naturally in the mouth, gastrointestinal tract and vaginal tract. The specific Lactobacillus fermentum used in Bio360® has shown benefits for digestive health* and effectively support vaginal health* as part of a multispecies formulation.20,21 Lactobacillus fermentum strains have also been studied for health of expectant mothers and new-borns*, immune health benefits in athletes*, and for cholesterol-lowering* properties.22,23,24


19. Garcia A. et al, Characterization of Lactobacillus fermentum UCO-979C, a probiotic strain with a potent anti-Helicobacter pylori activity. Electronic Journal of Biotechnology. 2017:25:75-83

20. Zhao X, et al. Preventive Effect of Lactobacillus fermentum Zhao on Activated Carbon-Induced Constipation in Mice. J Nutr Sci Vitaminol (Tokyo). 2015;61(2):131-137.

21. Mezzasalma V, et al. Orally administered multispecies probiotic formulations to prevent uro-genital infections: a randomized placebo-controlled pilot study [published correction appears in Arch Gynecol Obstet. 2017 Feb;295(2):527]. Arch Gynecol Obstet. 2017;295(1):163-172.

22. Anukam KC, et al. Improved appetite of pregnant rats and increased birth weight of newborns following feeding with probiotic Lactobacillus rhamnosus GR-1 and L fermentum RC-14. J Appl Res. 2005;5:46–52.

23. West NP, et al. Lactobacillus fermentum (PCC®) supplementation and gastrointestinal and respiratory-tract illness symptoms: a randomised control trial in athletes. Nutr J. 2011;10:30.

24. Pereira D, et al. An in vitro study of the probiotic potential of a bile-salt-hydrolyzing Lactobacillus fermentum strain, and determination of its cholesterol-lowering properties. Applied and Environmental Microbiology. 2003;69(8):4743-4752.

Strain 5: Lactobacillus paracasei

Lactobacillus paracasei

Lactobacillus paracasei rounds out our proprietary five-strain blend that is backed by over 700 studies. The specific Lactobacillus paracasei strain in Bio360® is known for its immuno-modulating properties* and can support immune health*.25 Lactobacillus paracasei strains have also shown benefits for managing a balanced inflammatory response* and addressing leaky gut*.25



25. Delgado S, et al. Molecules Produced by Probiotics and Intestinal Microorganisms with Immunomodulatory Activity. Nutrients. 2020;12(2):391.

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